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By J. Barnhill

ISBN-10: 9535100025

ISBN-13: 9789535100027

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There is substantial evidence supporting this notion. 24 Bipolar Disorder – A Portrait of a Complex Mood Disorder Lithium by itself facilitates LTP in hippocampal subregions. , 2007), respectively. , 2007). Son et al. (2003) showed that acute and chronic lithium treatment enhanced LTP in the dentate gyrus of the rat. They argued that LTP enhancing effect of lithium was mediated through upregulation of signaling molecules like BDNF, phosphorylated MAPK, phosphorylated CREB, CaMK II, phosphorylated Elk, and TrkB, but not through increased neurogenesis.

The mood stabilizers lithium and valproate selectivity activate the promoter IV of brainderived neurotrophic factor in neurons. Molecular Psychiatry 14( 1),pp. 51-59 ISSN 1359-4184 2 Anti-Stress Effects of Mood Stabilizers and Relevance to Their Therapeutic Actions Young-Ki Chung and Seungmin Yoo Department of Psychiatry, Ajou University School of Medicine South Korea 1. , 1996). , 1997). , 2008). The original concept of the mood stabilizer was the agent that was effective in treating acute manic episodes and preventing their relapses, thus “stabilizing” the manic pole of bipolar disorder (Stahl, 2008).

121-136), ΙSSN. , Kole, M. , Veenema, A. , de Boer, S. , Korte, S. &Koolhaas, J. M. (2005). Long-Term Effects of Social Stress on Brain and Behavior: A Focus on Hippocampal Functioning. 1, (Feb, 2005), pp. (83-97), ΙSSN. 0149-7634 (Print) Cade, J. F. (1949). Lithium Salts in the Treatment of Psychotic Excitement. 10, (Sep 3, 1949), pp. (349-352), ΙSSN. 0025-729X (Print) Cameron, H. &McKay, R. D. (2001). Adult Neurogenesis Produces a Large Pool of New Granule Cells in the Dentate Gyrus. 4, (Jul 9, 2001), pp.

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Bipolar Disorder - A Portrait of a Complex Mood Disorder by J. Barnhill


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