New PDF release: Batman Black and White Edition 3

By Klaus Janson, Andrew helfer et al

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Although they are very useful, transgenic and mutant mice have drawbacks that obscure a direct analysis of the expected phenotypes. Genetic redundancy and developmental plasticity are especially important issues that often impair the direct identification of gene function. In addition, it is a complex task to produce mice tailored to the needs of lung physiologists, because the lung is a very complex organ with numerous resident as well as motile cell types. To supplement this technical resource, other animal models, especially those, which have a far lesser complexity, would greatly facilitate research in this area.

Proc Natl Acad Sci USA 98:10892–10897 Grubeck-Loebenstein B (1997) Changes in the aging immune system. Biologicals 25:205–208 Hayek MG et al (1997) Vitamin E supplementation decreases lung virus titers in mice infected with influenza. J Infect Dis 176:273–276 Hilbi H, Weber SS, Ragaz C, Nyfeler Y, Urwyler S (2007) Environmental predators as models for bacterial pathogenesis. Environ Microbiol 9:563–575 Hoshino K et al (2008) Evaluation of Caenorhabditis elegans as the host in an infection model for food-borne pathogens.

These data show that L. pneumophila is virulent even on peptone-free mNGM if the targets are elderly worms. Our previous study showed that Salmonella is clearly virulent to both older and younger worms, although more so in elderly worms (Ikeda et al. 2007). These findings appear to be similar to the epidemiological characteristics of both pathogens in humans: Legionella tends to infect older people in an opportunistic manner, while Salmonella can cause enteritis irrespective of host age. 24 T. Komura et al.

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Batman Black and White Edition 3 by Klaus Janson, Andrew helfer et al


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